Needle-free drug delivery technology Challenge Increase the dose volume of a needle-free, pre-filled drug delivery technology. Approach Working across various departments and using our expertise in mathematical modelling and fluid dynamics, we tested the initial delivery system before carrying out industrial design and human factors HF studies leading to a range of prototypes.
Outcome The result was a safe and ergonomic platform device that can target a range of delivery volumes without affecting manufacturing cost. Our approach Team was asked to carry out an overall system, sub-system, component and preliminary process development through to proof-of-principle based upon completion of a physical laboratory model and its testing.
Outcome Via early stage HF analysis methods and industrial design input we were able to create an ergonomic platform device which will be safe and intuitive to use, non-threatening and appealing to users. Drug delivery. Wonder how we could help? Clinical trials have shown that the needle-free system is bioequivalent to needle-based injection systems, easy to use, and capable of providing rapid and effective symptom relief for many migraine episodes.
Sumavel DosePro is an effective treatment for migraine and should be part of the therapeutic armamentarium, particularly in cases where a rapid onset of action is critical or where oral administration is problematic. Keywords: autoinjector; migraine; needle-free; sumatriptan; triptan. Sumatriptan has been in use for the treatment of acute migraine headache for almost 2 decades. Injectable sumatriptan proved to be a revolutionary drug, empowering millions of individuals who experience moderate to severe intensity acute migraine headache.
Self-administered injectable sumatriptan has offered such individuals a safe and rapidly effective therapy far superior to the dismal options of either suffering in silence at home or seeking care at an emergency department or other health care facility.
While the oral triptans undeniably have benefited many migraine sufferers, they all are most consistently effective when taken at a relatively early stage in the migraine attack. None is as effective — and as rapidly effective — as injectable sumatriptan in treating migraine headache that has reached the moderate to severe level of intensity.
While patients experience a similarly minor degree of typically brief pain at the injection site regardless of which delivery system is used, autoinjector or DosePro, studies have indicated that Sumavel DosePro is well tolerated and simple to use.
If Sumavel DosePro is administered into the thigh or abdomen, the dose received 6 mg is biologically equivalent to an equal dose administered via the needle-based autoinjector.
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