Patients were enrolled with neuropathic pain associated with spinal cord injury that persisted continuously for at least three months or with relapses and remissions for at least six months. The patients had a minimum mean baseline pain score of greater than or equal to 4 on an point numerical pain rating scale ranging from 0 no pain to 10 worst possible pain. The baseline mean pain scores across the two studies ranged from 6.
Patients were allowed to take opioids, non-opioid analgesics, antiepileptic drugs, muscle relaxants, and antidepressant drugs if the dose was stable for 30 days prior to screening. Patients were allowed to take acetaminophen and nonsteroidal anti-inflammatory drugs during the studies. The week study consisted of a 3-week dose adjustment phase and a 9-week dose maintenance phase.
The week study consisted of a 4-week dose adjustment phase and a week dose maintenance phase. Lundbeck Takeda Pharmaceuticals U. Lyrica pregabalin Profile. Profile Contact Information Contact: Pfizer. Currently Enrolling Trials Show More. Lyrica pregabalin - 4 indications Scroll down for information on each indication: the management of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia; approved December the adjunctive treatment partial-onset seizures in patients 1 month of age and older; approved June the treatment of fibromyalgia; approved June the management of neuropathic pain associated with spinal cord injury; approved June General Information Lyrica pregabalin is a modulator of voltage-gated calcium channels, designed to affect neurological transmission in multiple systems.
There is no test for the diagnosis of fibromyalgia. Doctors make a diagnosis by conducting physical examinations, evaluating symptoms, and ruling out other conditions. Individuals with fibromyalgia have been shown to experience pain differently from other people. Studies have shown that such patients have decreased pain after taking Lyrica, but, the mechanism by which Lyrica produces such an effect is unknown. Two double-blind, controlled clinical trials, involving about 1, patients, support approval for use in treating fibromyalgia with doses of milligrams or milligrams per day.
The most common side effects of Lyrica include mild-to-moderate dizziness and sleepiness. Blurred vision, weight gain, dry mouth, and swelling of the hands and feet also were reported in clinical trials.
Its generic name is pregabalin. The cause of fibromyalgia is unknown, and no test exists to confirm a diagnosis. Doctors rely on patient complaints of symptoms and subjective responses to physical exams. Patients may try dietary changes or exercise, or antidepressants, pain relievers and other medicines to ease symptoms.
Fibromyalgia patients experience pain differently than others, and are thought to be more sensitive to stimuli that are not normally painful. The other medications are Cymbalta duloxetine and Savella milnacipran. Fibromyalgia is believed to involve over-active nerves and dysregulation of neurotransmitters chemical messengers that transmit messages, including pain signals, between brain cells. Scientists don't understand exactly how Lyrica improves fibromyalgia symptoms.
However, the drug is believed to slow down certain impulses in the brain and stop over-active nerves from misfiring. It also may affect the way certain neurotransmitters function. Although it's been approved for several years, research has continued on Lyrica as a fibromyalgia treatment. Of course, for it to be FDA approved, numerous clinical trials had to show that it could provide significant improvements in fibromyalgia pain , fatigue, and quality of life.
However, Lyrica doesn't work for everyone with fibromyalgia. Some research suggests that the three FDA-approved fibromyalgia drugs—Lyrica, Cymbalta, and Savella—are all about equally effective. Combining two drugs may be more beneficial, though.
A study published in the journal Pain suggests that combining Lyrica and Cymbalta may be more effective than either drug on its own, and the authors urged more research into combined treatments. The usual dose of Lyrica for fibromyalgia is mg to mg per day, split between two or three doses.
Generally, healthcare providers recommend starting at a low dosage, such as 75 mg twice a day, and working up gradually to a larger dose. If you decide to go off of Lyrica, talk to your practitioner about the proper way to wean off.
It's dangerous to stop taking Lyrica suddenly. The list of possible side effects is long. Some are serious enough that you should contact your healthcare provider immediately if you have them.
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